• The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study 

      Bonet, Catalina; Crous-Bou, Marta; Tsilidis, Konstantinos K.; Gunter, Marc J.; Kaaks, Rudolf; Schulze, Matthias B.; Turzanski Fortner, Rénee; Antoniussen, Christian S.; Dahm, Christina C.; Mellemkjær, Lene; Tjønneland, Anne; Amiano, Pilar; Ardanaz, Eva; Colorado-Yohar, Sandra M.; Rodriguez-Barranco, Miguel; Tin Tin, Sandar; Agnoli, Claudia; Masala, Giovanna; Panico, Salvatore; Sacerdote, Carlotta; May, Anne M.; Borch, Kristin Benjaminsen; Rylander, Karin Charlotta Maria; Skeie, Guri; Christakoudi, Sofia; Aune, Dagfinn; Weiderpass, Elisabete; Dossus, Laure; Riboli, Elio; Agudo, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-29)
      Evidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among BC survivors. Our study ...
    • Associations of gene expression in blood with BMI and weight changes among women in the Norwegian Women and Cancer postgenome cohort 

      Baiju, Nikita; Rylander, Karin Charlotta Maria; Sætrom, Pål; Sandanger, Torkjel M; Nøst, Therese Haugdahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-07)
      Objective: This study aimed to evaluate associations between blood gene expression profiles and (1) current BMI and (2) past weight changes (WCs) among women who had never been diagnosed with cancer in the Norwegian Women and Cancer (NOWAC) postgenome cohort.<p> <p>Methods: This cross-sectional study (N = 1694) used gene expression profiles and information from three questionnaires: Q1 (baseline), ...
    • Dietary patterns in relation to incidence rate of pancreatic cancer – the Norwegian women and cancer cohort study. 

      Selinger, Eliska; Rylander, Karin Charlotta Maria; Skeie, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-29)
      Despite development in cancer treatment and prevention options during the past few years, cancer of the pancreas remains a diagnosis associated with poor prognosis and limited options for prevention. Diet has proven to be an important risk factor for development of many types of cancer, particularly for cancers of the digestive system. Still, evidence regarding its relation to pancreatic cancer ...
    • Fluorine Mass Balance, including Total Fluorine, Extractable Organic Fluorine, Oxidizable Precursors, and Target Per- and Polyfluoroalkyl Substances, in Pooled Human Serum from the Tromsø Population in 1986, 2007, and 2015 

      Cioni, Lara; Plassmann, Merle; Benskin, Jonathan P.; Coelho, Ana Carolina; Nøst, Therese Haugdahl; Rylander, Karin Charlotta Maria; Nikiforov, Vladimir; Sandanger, Torkjel Manning (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-25)
      Of the thousands of per- and polyfluoroalkyl substances (PFAS) known to exist, only a small fraction (≤1%) are commonly monitored in humans. This discrepancy has led to concerns that human exposure may be underestimated. Here, we address this problem by applying a comprehensive fluorine mass balance (FMB) approach, including total fluorine (TF), extractable organic fluorine (EOF), total oxidizable ...
    • The impact of COVID-19-related restrictions on pregnancy and abortion rates in the Republic of Georgia 

      Khachidze, Nia; Manjavidze, Tinatin; Anda, Erik Eik; Nedberg, Ingvild Hersoug; Sandøy, Ingvild Fossgard; Rylander, Karin Charlotta Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-18)
      Background The Republic of Georgia implemented COVID-19-related restrictions starting on 31 March 2020, when it imposed a 1-month strict lockdown, after which the country continued with some form of restrictions for 1 year. These restrictions created barriers to healthcare access, affected healthcare services, caused severe economic degradation, and changed reproductive behavior. The aim of this ...
    • Legacy perfluoroalkyl acids and their oxidizable precursors in plasma samples of Norwegian women 

      Miranda Fernandes Coelho, Ana Carolina; Cioni, Lara; Van Dreunen, Wendy; Berg, Vivian; Rylander, Karin Charlotta Maria; Urbarova, Ilona Halva; Herzke, Dorte; Sandanger, Torkjel M (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-12)
      Humans are exposed to perfluoroalkyl acids (PFAA) mainly through direct pathways, such as diet and drinking water, but indirect exposure also occurs when PFAA precursors break down to form legacy PFAA. Exposure to PFAA precursors raises particular concern, as neither the exposure nor the precursors themselves have been well described. In the present study, we aimed to assess the indirect contribution ...
    • Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis 

      Charles, Dolley; Berg, Vivian; Nøst, Therese Haugdahl; Wilsgaard, Tom; Bergdahl, Ingvar A.; Huber, Sandra; Ayotte, Pierre; Averina, Maria; Sandanger, Torkjel M; Rylander, Karin Charlotta Maria (Journal article; Tidsskriftartikkel, 2023-03-05)
      <p><i>Background:</i> Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between ...
    • Pre-diagnostic intake of vitamin D and incidence of colorectal cancer by anatomical subsites: the Norwegian Women and Cancer Cohort Study (NOWAC) 

      Paulsen, Elise Marlen; Rylander, Karin Charlotta Maria; Brustad, Magritt; Jensen, Torill Miriam Enget (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-09)
      According to the World Cancer Research Fund International, vitamin D might decrease the risk of colorectal cancer (CRC). However, less is known about the association with cancers in different subsites of the colon and in the rectum. The aim of this study was to examine associations between pre-diagnostic intake of vitamin D and risk of CRC by anatomical subsites. Data from 95 416 participants in the ...
    • Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer 

      Busund, Marit Katinka; Ursin, Giske; Lund, Eiliv; Wilsgaard, Tom; Rylander, Karin Charlotta Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-28)
      Background - Body fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and postmenopausal breast cancer, we aimed to examine the age at onset, duration, intensity, and trajectories of body fatness in adulthood in relation to risk of breast cancer subtypes.<p> <p>Methods - Based on self-reported anthropometry in the prospective ...